Balls Hen House Pharmacy

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Volume 6, Issue 11

Cold Sores
Contributed by: Jennifer Easton, Pharm.D. Candidate
                      KU School of Pharmacy

June 2008

Herpes labialis, more commonly known as cold sores or fever blisters, is an infection caused by the herpes simplex virus (HSV).  While cold sores are usually caused by HSV-1, either virus type (HSV-1 or HSV-2) can cause sores around the lips, mouth, etc.

Stages

  • Burning, itching, or tingling sensation may occur 1-2 days before the cold sore appears (known as prodrome)
  • Formation of small, painful, fluid-filled blisters
  • Blisters break open, releasing a clear fluid
  • Blisters dry and scab over, forming a yellow crust that eventually falls off
  • Underlying skin begins to heal

Common triggers
  • Fever
  • Emotional stress
  • Menstrual periods
  • Sun exposure

Treatment
While cold sores usually heal in 7-10 days without treatment, there are medications that may reduce the frequency and/or duration of outbreaks if started at the first sign of a cold sore:
  • Topical medications
§ Docosanol 10% cream (Abreva®)
§ Acyclovir 5% cream or ointment (Zovirax®)
§ Penciclovir 1% cream (Denavir®)


  • Oral medications
§ Acyclovir tablets/capsules (Zovirax®)
§ Valacyclovir caplets (Valtrex®)
§ Famciclovir tablets (Famvir®)
  • Medications used to decrease pain and discomfort
§ Topical lidocaine or benzocaine
§ OTC pain relievers - aspirin, acetaminophen, ibuprofen, naproxen
  • Contact your physician for prescription/dosing

Prevention
  • Avoid skin contact such as kissing or sharing items such as eating utensils, toothbrushes, towels, razors, lipstick, etc. when blisters are present
  • Wash your hands and do not touch the cold sore to avoid spreading the virus to other areas of the body or to other people
  • NOTE: There is no cure for herpes, and it is still possible to spread the herpes virus even when symptoms/sores are not present

For additional information talk with you pharmacist or physician or visit www.mayoclinic.com or www.webmd.com.

Co-edited by:
Sarah Hare, Pharm.D.
Kristian Olsen, Pharm.D.

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