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With the impending switch of metered dose inhalers (MDI) such as Proventilâ (albuterol) from chlorofluorocarbon (CFC) based to hydrofluoroalkane (HFA) based, many patients are becoming confused. This article will answer some common questions regarding the switch and help patients to become comfortable with their new inhaler.
What are CFC and HFA?
Chloroflurocarbons (CFC) and hydrofluoroalkanes (HFA) are safe compounds used in many common devices as a propellant. Certain inhalers use CFC or HFA to propel its active drug past the mouth and into the lungs where an effect is observed.
Why are inhalers no longer allowed to contain CFC?
Although CFC is safe for humans, it is toxic to our ozone layer. The ozone layer acts as a filter preventing the sun's harmful ultraviolet light from damaging life on earth. After CFC is propelled from its device, it floats into the atmosphere where the sun breaks the CFC molecule into chlorine. Chlorine causes holes to form in the ozone
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layer thus allowing the dangerous ultraviolet light to reach earth. Among other things, ultraviolet light can increase the risk of skin cancer and eye damage. The propellant HFA has been found to be more ozone friendly.
Despite a different taste and/or feeling, HFA inhalers deliver a correct amount of drug into the lungs.
HFA inhalers require more frequent cleaning. To clean the inhalers first remove the cap and metal canister. Wash the mouthpiece by allowing warm water to flow through the top and bottom for 30 seconds. Allow the mouthpiece to dry (preferably overnight) before replacing the cap and metal canister. For HFA inhalers, this process may need to be repeated every three to five days.
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Are HFA inhalers available in generic?
Since a new formulation using HFA was created, HFA inhalers are now only available in brand name. Unfortunately this may mean higher co-pays for most patients until generic HFA inhalers become available in a few years. Please refer to the chart below to determine the brand names of the new HFA inhalers.
When will CFC inhalers be completely eliminated?
Although CFC inhalers are being slowly phased out, they will eventually be completely banned from the market. Albuterol CFC inhalers will be the first to be banned from the market, beginning December 31, 2008.
For more information please visit: www.fda.gov/cder/mdi or www.inhalertransition.org/.
As always, feel free to contact your local pharmacist if you have any questions.
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